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LOW DOSE RATE BRACHYTHERAPY CALIBRATIONS
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The IVB1000 Well Chamber or the HDR 1000 Plus Well Chamber can be used for the measurement of low dose rate isotope sealed sources. A range of different isotope source holders are available for all existing low dose rate isotopes. New source
holders are now available for intravascular brachytherapy. The IVB1000 Well Chamber has the advantage that it is a longer chamber and has a 10 cm linear sensitive region compared to the 5 cm linear sensitive region of the HDR 1000 plus.
For low dose rate brachytherapy, the standard of practice has shifted so that the manufacturer's calibration alone is no longer adequate. "However, it is the responsibility of the institution to verify that this calibration is correct. the institution should compare the manufacturer's stated value with the institution's standard." ref. Comprehensive QA for
radiation oncology: Report of AAPM Radiation Therapy Committee Task Group 40 Med. Phys. 21(4):581-618, 1994. The HDR 1000 Plus is that standard!
HDR 1000 plus well chamber Source Holders ( or go to IVB 1000 Source Holders )
Individual Seed Calibration for Prostate Cancer Treatment
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| Source Holder for Single Seed Measurements, SeeDOS Code 70016 This insert has a 1.2mm inner diameter Teflon® tube which positions an individual iodine, palladium, iridium, or gold seed at the most sensitive area of the Standard Imaging HDR 1000 Plus Ion Chamber. The smooth Teflon tube allows easy removal of the seed. Ion
chamber calibrations from the University of Wisconsin ADCL are available for iodine and palladium. |
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Batch Assay Measurements
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| Source Holder for Seed Batch Assay, SeeDOS Code 70022
LDR brachytherapy treatment for prostate cancer measures high numbers of seeds. A treatment center must sometimes receive up to 500 seeds if several cases are imminent. Individual seed calibration is too time consuming and cumber-some. For these large number of seeds, a random sampling of at least 10% of the seeds should be calibrated.
Multiple seed measurements are performed with the Source Holder for LDR Seed Batch Assay, SeeDOS Code 70022. This source holder holds up to 500 of the iodine or palladium seeds typically used for prostate cancer treatment.
Seeds are positioned at the most sensitive area of the HDR 1000 Plus Ion Chamber. If one has the Source Holder 70016 with an ADCL calibration for the isotope being measured, that calibration can be transfered to Source Holder 70022.
Self absorption resulting from a large number of seeds being placed in the insert is significant. Because of this self absorption, correction factors must be experimentally obtained for each type of LDR seed used. This method is described in detail in Med. Phys. 22 (9) Sept. 1995. Note, a correction factor for iodine and palladium as shown in Fig. 2 of this article,
should be determined for each individual well chamber upon receipt of the chamber.
Before each assay procedure, a constancy check should be performed to assure the integrity of the calibration system. This should be done with a long half-life isotope like caesium.
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Output Measurement of I-125 RAPID Strand™ Iodine Seeds
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A fast and convenient method of performing a quality assurance measurement of your I-125 RAPID Strand™ using the Source Holder 70023 under sterile conditions.
- The sterile insert maintains sterility of the I-125 RAPID Strand™.
- Five seeds are measured simultaneously.
- QA measurements within + 5% of calibrated IMC6711 I-125 Seeds™.
- Short term precision is < 1%.
- No measurable rotational dependence.
- The complete calibration system is lightweight and easily portable for use in a sterile environment.
The I-125 RAPID Strand™ Source Holder 70023 is constructed to simultaneously measure five seeds at one end of the I-125 RAPID Strand™ while the I-125 RAPID Strand™ remains in the spacing jig. The spacing jig is then inverted and the five seeds at the other end are measured. The source holder itself can be sterilized.
To determine the activity of your I-125 RAPID Strand™, a correction factor has been determined. A I-125 RAPID Strand™ containing 10 iodine seeds was obtained and an extensive evaluation was performed with the HDR 1000 Plus and the I-125 RAPID Strand™ Source Holder 70023. Following the evaluation, individual seeds of the I-125 RAPID Strand™ were cut from the strand and
individually calibrated. To obtain a correction factor, these measurements were compared to the initial, collective seeds measurements of the intact I-125 RAPID Strand™ in Source Holder 70023. |
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MICK™ Magazine Cartridges
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Source Holder for Measurements of Loaded MICK™ Magazine Cartridges, SeeDOS Code 70024
- QA Measurements for Dose Verification
- No Rotational Dependence
- Fast Measurements
- Iodine or Palladium Seeds
A Source Holder has been designed for the HDR 1000 Plus Brachytherapy Well Chamber which provides a quick and convenient QA measurement of loaded MICK™ Magazine Cartridges. This Source Holder positions the seeds at the centre of the well chamber for quick, reproducible measurements. |
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Bard EXPRESS Seeding Cartridge
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- Quality Assurance measurements within 5% of calibrated seeds
- Measurement reproducibilty better than 1%
- No rotational dependence
- A quick calculation provides the average seed activity
Source Holder for Bard EXPRESS Seeding Cartridge, SeeDOS Code 70032 positions loaded cartridges at the most sensitive position of the HDR 1000 Plus, providing a check of the relative activity of the seed held within the cartridge. The source holder accommodates Bard Seeding Cartridges with 2 to 6 seeds and can be gas or steam sterilized. |
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Low Dose Source Rate Iridium Source Holders
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| Source Holder for Low Dose Rate 192 Ir Ribbon Seeds, SeeDOS Code 70009 has a 3mm diameter acrylic tube which extends from the top of the insert to the most active area of the chamber. It makes one loop at the active area and extends back to the top of the insert. A collective calibration of the entire ribbon of seeds is
obtained. Fourteen iridium seeds spaced one centimetre centre to center can fit into the active area. Some intravascular brachytherapy sources can be measured in this insert. |
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| Source Holder for Measurement of Iridium Wire Coils, SeeDOS Code 70022 The iridium wire coil is placed in the tube and uniformly compressed to 2mm for measurement at the most sensitive point of the ion chamber. This consistent positioning provides for excellent measurement reproducibility. Short term reproducibility is 0.6%.
Linearity over a range of 124 to 2036 MBq is better than 0.1%. |
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Caesium Source Holders
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| Source Holder for Caesium, SeeDOS Code 70020 has a 5mm diameter opening and is commonly used with manually loaded caesium sources. A spacer within the source holder positions the caesium insert at the most active area of the chamber. The spacer for positioning the caesium source is removable so that the insert can also be used
with some longer caesium sources, and with larger HDR 192 Ir catheters. |
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| Source Holder for Cesium Remote Afterloading, SeeDOS Code 70003 has a 7.1mm diameter opening. This insert is used with LDR remote afterloading treatment systems. There is no spacer because the afterloading system positions the sources. This insert can also be used with cobalt sources used in some LDR remote afterloading
treatment systems. |
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Others
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| Source Holder for Measurement of Metastron™ (Strontium-89 Chloride Injection), SeeDOS Code 70026 has been designed for the HDR 1000 Plus Brachytherapy Well Chamber which provides a quick and convenient QA measurement of Metastron vials. Source Holder 70026 for 5 cc and 10 cc Metastron Syringes, includes one set of two syringe
holders, one for a 5 cc syringe and one for a 10cc syringe. |
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| One Inch Lead Shielding Ring, SeeDOS Code 70025. This shielding ring is made of one inch thick lead which surrounds the HDR 1000 Plus Brachytherapy Well Chamber. It is constructed of four interlocking rings to shield the user during measurement. |
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IVB 1000 well chamber Source Holders
Novoste Source Holder for 90SR/90Y IVB Sources (SeeDOS Code 70036)
Centres the source in the active area of the well chamber for measurement. The collar is adjustable for sources of 30, 40 and 60 mm lengths. This source holder accommodates both the 3.5 and 5.0 mm french catheters. |
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X-Ray Contamination Test Tool (SeeDOS Code 70042)
Designed for use with 90Sr/90Y sources only. It consists of a 7mm thick wall of Delrin that absorbs nearly all of the beta particles. It allows only the bremsstrahlung radiation to pass through the source holder for measurement. |
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Source Holder for Iridium IVB Sources (SeeDOS Code 70034)
Centres the source train in the active area of the well chamber for a measurement. The source holder is adjusted to accommodate the number of seeds in the source to be measured.
The collar is adjustable to measure 6, 10, 14, 18, or 22 seeds. |
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Source Holder for HDR Iridium (SeeDOS Code 70044)
Designed for high dose rate iridium measurements. It has a 2.2 mm
diameter opening for the catheter. A rubber O-ring secures the catheter with a uniform constricting pressure to prevent any movement of the catheter. |
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Source Holder for Single LDR Seeds (SeeDOS Code 70043)
Designed to position an individual LDR brachytherapy seed, such as
Iodine, Iridium or Palladium, for a measurement. This source holder has a 1.2 mm diameter opening.
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Preloaded Needle Source Holder (SeeDOS Code 70051)
Allows calibration and visual verification of a sterilized needle filled with seeds and spacers. The sterilized needle is fitted to the sterilized source holder through a luer lock fitting. The universal luaer lock mates to the needle through an adjustable needle hub to needle opening interface offering seamless integration from seeds to the needle. Seeds are dropped into the source
holder channel where they allow visual verification of seed and spacer sequence. They are then placed into the well chamber for absolute calibration. Source trains of one to ten seeds may be verified and calibrated while maintaining sterility. |
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Source Holder for RAPID Strand™ Iodine Seeds (SeeDOS Code 70048)
Provides a fast and convenient method to perform a quality assurance measurement of the I-125 RAPID Strand™ under sterile conditions. This source holder is constructed to simultaneously measure the ten 6711 seeds in the strand. A correction factor has been determined to calculate the activity. |
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Source Holder for MICK® Cartridges (SeeDOS Code 70047)
Provides a consistency QA check of the activity of seeds loaded into a MICK cartridge. This source holder positions the cartridge for a quick, reproducible measurement. Spring-loaded clamp attachment quickly grips cartridge to minimize finger dose. Works with the new
Shielded/Disposable Mick® Magazines. |
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Source Holder for Imagyn isosleeve™ (SeeDOS Code 70050)
Designed for QA measurements of the isosleeve™ prostate brachytherapy needle delivery system from Imagyn Medical Technologies. Each isosleeve™ needle is provided sterilized and custom-loaded according to the treatment plan. The polymide sleeve within the isosleeve™ needle contains the seeds and spacers and may be removed from the needle hub so that the seeds can be assayed in the
source holder. |
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Source Holder for IBt InterStrand® (SeeDOS Code 70049)
Designed for QA measurements of International Brachytherapy InterStrand® source trains. These consist of ten InterSource 103Pd seeds or ten InterSource 125I seeds, with an absorbable suture contained within the open annulus of each seed. The InterStrand® stainless steel shielding container connects to the top of the source holder of easy transfer of the InterStrand® to the source
holder for measurement. |
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Source Holder for Caesium (SeeDOS Code 70045)
Commonly used with manually loaded caesium sources this source holder has a 5.0 mm diameter opening. A spacer within the source holder positions the caesium insert for a measurement. The spacer, for positioning the caesium source, is removable. |
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Source Holder for Cesium Remote Afterloading (SeeDOS Code 70046)
Designed for use with LDR remote afterloading treatment systems, this source holder has a 7.1 mm diameter opening. There is no spacer because the afterloading system positions the source. |
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Source Holder for Measuring 5 cc and 10 cc syringes (SeeDOS Code 70026)
Provides a quick and convenient QA measurement of Metastron™ Sr89, Sm153, and I131 vials and most liquids in a 5 cc or 10 cc syringe. Source Holder 70026 includes one set of two syringe holders, one for a 5 cc syringe and one for a 10 cc syringe. |
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Calibrations
SeeDOS offers NIST traceable calibrations from the University of Wisconsin Accredited Dosimetry Calibration Laboratory. You need only one purchase order to cover calibrations, shipping, handling and service. All instruments are hand carried to the ADCL.
High Dose Rate Calibrations Available
HDR 192Ir
Low Dose Rate Calibrations Available
Caesium
LDR 192Ir
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Alpha Omega
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Best Industries
Iodine
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Oncura 6733 EchoSeed™
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North American Scientific IoGold
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International Isotopes IS-12500
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International Isotopes IS-12501
Palladium
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Theragenics Theraseed 200
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North American Scientific / Mentor MED3633
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Best Industries 2335
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International Brachytherapy 1031L
Several calibrations may be ordered for one insert, for example the Source Holder for Single LDR Seeds, 70016, can be calibrated for both iodine seeds 6711 and 6702.
If you are interested in any of the products, please complete an Enquiry Form or a Quotation Request Form, so that we
may
promptly respond to your request.
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Please contact Colin Walters at cwalters@seedos.com if you would like further information or you have questions
or comments about this web site.
SeeDOS Ltd, 26, The Maltings, Leighton Buzzard, Bedfordshire LU7 4BS, United Kingdom
Tel: +44 1525 850 670 • Fax: +44 1525 850 685
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